Gene Information
serine/threonine kinase 11 [Source:HGNC Symbol;Acc:HGNC:11389]
STK11 variants are associated with 1 disease including Peutz-Jeghers syndrome, with 46 documented clinical phenotypes.
The STK11 gene is associated with 1 medical condition, including:
Research has identified 46 phenotypic features associated with STK11 variants:
Bloody diarrhea
HP:0025085
Neoplasm of the pancreas
HP:0002894
Sporadic
HP:0003745
Biliary tract abnormality
HP:0001080
Clubbing of fingers
HP:0100759
Autosomal dominant inheritance
HP:0000006
Childhood onset
HP:0011463
Atypical nevi in non-sun exposed areas
HP:0001074
Oral melanotic macule
HP:0032451
Autosomal dominant inheritance
HP:0000006
Intussusception
HP:0002576
Clubbing
HP:0001217
Bile duct polyp
HP:0034352
Elevated circulating alpha-fetoprotein concentration
HP:0006254
Cutaneous melanoma
HP:0012056
ClinVar contains 10 variants associated with STK11. Below are some notable variants:
NC_000019.9:g.(?_1206912)_(1222006_?)dup
Likely pathogenicVCV004526428
Review: criteria provided, single submitter
NM_000455.5(STK11):c.*77GCCC[3]
Likely benignVCV004294402
Review: criteria provided, single submitter
NM_000455.5(STK11):c.1118del (p.Pro373fs)
PathogenicVCV004294265
Review: criteria provided, single submitter
NM_000455.5(STK11):c.465-1G>T
Likely pathogenicVCV004176615
Review: criteria provided, single submitter
NM_000455.5(STK11):c.797del (p.Asn266fs)
PathogenicVCV004176613
Review: criteria provided, single submitter
There are 1,160 publications about STK11 indexed in PubMed. Below are some recent papers:
Genomic insights and therapeutic efficacy of PARP inhibitors in a high-LOH patient-derived xenograft from malignant transformation of ovarian teratoma.
Nakagawa A, Tamauchi S, Xinyuan W
PMID: 41242305
•
2025 Nov 14
•
Biochem Biophys Res Commun
Lung Carcinoma Metastatic to Breast: A Comprehensive Analysis of Clinical Presentation, Morphologic and Molecular Features, with Emphasis on Diagnostic Pitfalls.
Hashmi AA, Vougiouklakis T, Gazzo A
PMID: 41241092
•
2025 Nov 13
•
Mod Pathol
Case Report: From teratoma to adenocarcinoma: molecular insights into somatic-type malignancy in testicular germ cell tumors - two case reports and review of the literature.
Rozsvai T, Pósfai B, Torday L
PMID: 41230344
•
2025
•
Pathol Oncol Res
Rationale and design for a phase IIIb trial of first-line tremelimumab plus durvalumab versus pembrolizumab, in combination with chemotherapy, in patients with non-squamous metastatic non-small-cell lung cancer and mutations or co-mutations in STK11, KEAP1, or KRAS: the TRITON study.
Skoulidis F, Borghaei H, Garon EB
PMID: 41209621
•
2025
•
Ther Adv Med Oncol
Targeting tumoral heterogeneity in lung cancer: a novel, CT-texture-guided targeted biopsy approach with exome sequencing.
Hertel A, Streuer A, Diehl S
PMID: 41203783
•
2025 Nov 7
•
NPJ Precis Oncol
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Last updated: 11/20/2025