Gene Information

STK11

serine/threonine kinase 11 [Source:HGNC Symbol;Acc:HGNC:11389]

protein_codingChromosome 19ENSG00000118046

Overview

STK11 variants are associated with 1 disease including Peutz-Jeghers syndrome, with 46 documented clinical phenotypes.


Associated Diseases

The STK11 gene is associated with 1 medical condition, including:

Peutz-Jeghers syndrome

MONDO:0008280


Clinical Phenotypes

Research has identified 46 phenotypic features associated with STK11 variants:

View all


ClinVar Variants

ClinVar contains 10 variants associated with STK11. Below are some notable variants:

NC_000019.9:g.(?_1206912)_(1222006_?)dup

Likely pathogenic

VCV004526428

Review: criteria provided, single submitter

NM_000455.5(STK11):c.*77GCCC[3]

Likely benign

VCV004294402

Review: criteria provided, single submitter

NM_000455.5(STK11):c.1118del (p.Pro373fs)

Pathogenic

VCV004294265

Review: criteria provided, single submitter

NM_000455.5(STK11):c.465-1G>T

Likely pathogenic

VCV004176615

Review: criteria provided, single submitter

NM_000455.5(STK11):c.797del (p.Asn266fs)

Pathogenic

VCV004176613

Review: criteria provided, single submitter


Recent Publications

There are 1,160 publications about STK11 indexed in PubMed. Below are some recent papers:

Genomic insights and therapeutic efficacy of PARP inhibitors in a high-LOH patient-derived xenograft from malignant transformation of ovarian teratoma.

Nakagawa A, Tamauchi S, Xinyuan W

PMID: 41242305

2025 Nov 14

Biochem Biophys Res Commun

Lung Carcinoma Metastatic to Breast: A Comprehensive Analysis of Clinical Presentation, Morphologic and Molecular Features, with Emphasis on Diagnostic Pitfalls.

Hashmi AA, Vougiouklakis T, Gazzo A

PMID: 41241092

2025 Nov 13

Mod Pathol

Case Report: From teratoma to adenocarcinoma: molecular insights into somatic-type malignancy in testicular germ cell tumors - two case reports and review of the literature.

Rozsvai T, Pósfai B, Torday L

PMID: 41230344

2025

Pathol Oncol Res

Rationale and design for a phase IIIb trial of first-line tremelimumab plus durvalumab versus pembrolizumab, in combination with chemotherapy, in patients with non-squamous metastatic non-small-cell lung cancer and mutations or co-mutations in STK11, KEAP1, or KRAS: the TRITON study.

Skoulidis F, Borghaei H, Garon EB

PMID: 41209621

2025

Ther Adv Med Oncol

Targeting tumoral heterogeneity in lung cancer: a novel, CT-texture-guided targeted biopsy approach with exome sequencing.

Hertel A, Streuer A, Diehl S

PMID: 41203783

2025 Nov 7

NPJ Precis Oncol

View all 1,160 publications on PubMed →

Analyze STK11 Variants with AI

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Trusted Data Sources

EnsemblMonarch InitiativeClinVarGeneReviewsPubMed

Last updated: 11/20/2025

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