Gene Information
RAD51 paralog D [Source:HGNC Symbol;Acc:HGNC:9823]
RAD51D is a protein coding located on chromosome 17.
The RAD51D gene is associated with 2 medical conditions, including:
ClinVar contains 10 variants associated with RAD51D. Below are some notable variants:
NM_002878.4(RAD51D):c.728_732del (p.Met243fs)
Likely pathogenicVCV004294211
Review: criteria provided, single submitter
NM_002878.4(RAD51D):c.658C>T (p.Gln220Ter)
PathogenicVCV004149914
Review: criteria provided, single submitter
NM_002878.4(RAD51D):c.580_583dup (p.Gly195fs)
Likely pathogenicVCV004071382
Review: criteria provided, single submitter
NM_002878.4(RAD51D):c.807C>A (p.Ser269Arg)
Uncertain significanceVCV004057159
Review: criteria provided, single submitter
NM_002878.4(RAD51D):c.536dup (p.Asp180fs)
Likely pathogenicVCV004056298
Review: criteria provided, single submitter
There are 271 publications about RAD51D indexed in PubMed. Below are some recent papers:
Cryo-electron microscopy visualization of RAD51 filament assembly and end-capping by XRCC3-RAD51C-RAD51D-XRCC2.
Greenhough LA, Galanti L, Liang CC
PMID: 41196948
•
2025 Nov 6
•
Science
Salpingectomy in individuals at high risk for tubo-ovarian cancer - consensus and precaution.
Wilke RN, Pennington KP, Gootzen TA
PMID: 41183726
•
2025 Nov 1
•
Am J Obstet Gynecol
Recontact and follow-up for individuals with germline pathogenic variants in hereditary breast and ovarian cancer susceptibility genes: a UK Cancer Genetics Group consensus meeting.
Christopher J, Edgerley K, McIldowie B
PMID: 41159931
•
2025 Oct 1
•
J Med Genet
Management of individuals with heterozygous germline pathogenic variants in RAD51C, RAD51D, and BRIP1: A clinical practice resource of the American College of Medical Genetics and Genomics (ACMG).
Ngeow J, Chiang J, Astiazaran-Symonds E
PMID: 41070818
•
2025 Nov
•
Genet Med
Genomic characterization of patients with colorectal cancer.
Mahdouani M, Zhuri D, Dusenkalkan F
PMID: 41013697
•
2025 Sep 26
•
Hered Cancer Clin Pract
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Trusted Data Sources
Last updated: 11/20/2025